Postdoctoral Research Scientist in Host-Pathogen interaction and Immunometabolism needed
THE OPPORTUNITY
An immediate Postdoctoral Research Scientist position is available in the laboratory of Dr. Sebastián A. Riquelme at Columbia University Irving Medical Center in New York. The mission of Dr. Riquelme lab is to understand how metabolism impacts the outcome of infectious diseases. We apply cutting-edge OMICs technologies, such as single-cell RNA-Seq, dual RNA-Seq, metabolomics, genome sequencing and proteomics to dissect host-pathogen crosstalk, putting emphasis on the immunometabolic pathways exploited by opportunists to thrive in the human lung. Our group studies Gram-negative and Gram-positive bacterial diseases, using both laboratory strains and clinical isolates obtained from the lung of acutely and chronically infected subjects. Our work is translational, employing both in vitro and in vivo models of infection to answer clinically relevant questions.
KEY RESPONSIBILITIES
To study how the host metabolic response to infection impacts the outcome of bacterial disease
To generate different in vivo models of bacterial pneumonia
Work independently, in an organized fashion, and in collaboration with the rest of lab members
Design and execute experiments in a timely manner, as well as analyze and discuss the findings obtained in laboratory meetings. Ensure laboratory notebook is well organized and legible
Troubleshoot experiments when necessary, using reasonable approaches
Conduct scientific research in a responsible manner following the institutional ethical guidelines
Actively write scientific manuscripts and funding applications
Present research data in national and international scientific meetings
PREFERRED QUALIFICATIONS
Applicants interested in this position should hold a recent PhD degree in Immunology, Microbiology, Cell Biology or related area.
The candidate will have a solid foundation in regulatory T cell (Treg) biology, with particular focus on infectious diseases
The applicant will have advanced experience using different in vivo models, including Treg-deficient (e.g., Foxp3-DTR, etc) and Cre-LoxP systems
Technical expertise required includes multicolor flow cytometry, T cell purification, qRT-PCR, ELISA, RNA-Seq, confocal microscopy, Seahorse assays, western blot, cell culture and bacterial culture.
Experience with pneumonia models of infection and generation of mutant bacteria is advantageous.
Training in bioinformatic analysis of big datasets, such as single-cell RNA-Seq transcriptomics, genomics, and metabolomics is valuable, but not essential.
GENERAL EXPERIENCE/QUALIFICATIONS
The candidate must have a doctorate degree (Ph.D. or MD)
The applicant can create data-driven hypotheses, using unbiased approaches for the generation of original, solid lines of research.
The candidate has strong interpersonal skills and the ability to build and sustain effective working relationships with professionals in different disciplines
To encourage both colleagues and staff to value each other’s contributions, promoting an inclusive and respectful environment
COMPENSATION
Compensation is competitive and commensurate with both experience, achievement, and standards recommended by NIH.
Columbia University is an Equal Opportunity/Affirmative Action employer —Race/Gender/Disability/Veteran.
This position has been filled. We are not currently accepting new
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